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quinupristin/dalfopristin will increase the level or outcome of quinine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unfamiliar.quinupristin/dalfopristin will boost the degree or influence of vardenafil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Vardenafil dose may